MS Treatments (2018)

First-line therapy

  1. Avonex – Interferon beta-1a (Biogen)
    • Brand Name: Avonex
    • Chemical Name: interferon beta-1a
    • MS type: Relapsing forms of MS include individuals with secondary-progressive MS who continue to experience relapses or acute attacks
    • Administration: Taken by injection; once a week
    • Slows the progression of disability and reduces the frequency of relapses by 30%
    • Click here to read the prescribing information
  2. Rebif – Interferon beta-1a (Serono)
    • Brand Name: Rebif
    • Chemical Name: Interferon beta-1a
    • MS type: Relapsing forms of MS include individuals with secondary-progressive MS who continue to experience relapses or acute attacks
    • Administration: Taken by injection; on the same three days a week
    • Reduces the number of relapses by up to 30% and reduces the severity of relapses. Slows the progression of disability
    • Click here to read the Rebif prescribing information
  3. Extavia – Interferon beta-1b (Novartis)
    • Brand Name: Extavia
    • Chemical Name: Interferon beta-1b
    • MS type: Relapsing forms of MS include individuals with secondary-progressive MS who continue to experience relapses or acute attacks
    • Administration: Taken by injection; every other day
    • Click here to read the Prescribing Information for healthcare professionals
    • Click here to read the Medication Guide for patients
  4.  Betaseron – Interferon beta-1b (Bayer)
    • Brand Name: Betaseron
    • Chemical Name: Interferon beta-1b
    • MS type: Relapsing forms of MS include individuals with secondary-progressive MS who continue to experience relapses or acute attacks
    • Administration: Taken by injection; every other day
    • Delay in the progression from first clinical event (CIS) to clinically definite MS. 30% reduction in relapses and reduction in severity of relapses
    • Click here to read the Betaseron Medication Guide
  5. Glatiramer acetate (Mylan)
    • Brand Name: Glatiramer Acetate Injection
    • Chemical Name: glatiramer acetate (therapeutic equivalent to Copaxone 40mg/mL dose and 20 mg/mL dose)
    • MS type: Relapsing forms of multiple sclerosis
    • Administration: Taken by injection; two dose strengths: 40 mg/mL for 3-times-a-week injection and 20 mg/mL for one-daily injection
    • Reduces the number of relapses by up to 30%
    • Click here to read the FDA prescribing information
  6. Copaxone (Teva)
    • Brand Name: Copaxone
    • Chemical Name: Glatiramer acetate
    • MS type: Relapsing forms of multiple sclerosis
    • Administration: Taken by injection; two dose strengths: 40 mg/mL for 3-times-a-week injection and 20 mg/mL for one-daily injection
    • Reduces the number of relapses by up to 30%
    • Click here to read the FDA Prescribing Information for healthcare professionals
  7. Glatopa (Glatopa)
    • Brand Name: Glatopa (generic equivalent of Copaxone 20mg and 40mg)
    • Chemical Name: Glatiramer acetate
    • MS type: Relapsing forms of multiple sclerosis
    • Administration: Taken by injection; substitutable for Copaxone 20mg (taken daily) and Copaxone 40mg (taken 3 times a week)
    • Click here to read the FDA Prescribing Information
  8. Tecfidera (Biogen)
    • Brand Name: Tecfidera
    • Chemical Name: Dimethyl fumarate
    • MS type: Relapsing forms of MS include individuals with secondary-progressive MS who continue to experience relapses or acute attacks
    • Administration: Oral medication in capsule form; two times per day
    • Slows the progression of disability and reduces the frequency of relapses by up to 50%
    • Click here to read the Tecfidera Prescribing Information for healthcare professionals
    • Click here to read the Tecfidera Patient Information
  9. Plegridy (Biogen)
    • Brand Name: Plegridy
    • Chemical Name: Peginterferon beta-1a
    • MS type: Relapsing forms of MS
    • Administration: Taken by injection; once every 14 days
    • Slows the progression of disability and decreases the frequency of relapses by up to 30%
    • Click here to read the Plegridy prescribing information for healthcare providers
    • Click here to read the Plegridy Medication Guide for patients
  10. Aubagio (Sanofi Genzyme)
    • Brand Name: Aubagio
    • Chemical Name: Teriflunomide
    • MS type: Relapsing forms of MS
    • Administration: Oral medication in tablet form; once a day
    • It reduces the number of relapses by up to 36%
    • Click here to see the FDA prescribing information for healthcare professionals
    • Click here to see the FDA Medication Guide for patients
  11. Mavenclad (Merck)
    • Brand Name: Mavenclad
    • Chemical Name: Cladribine
    • MS type: Adults with RRMS whose disease remains active whilst on anyone other DMT or those with very active MS (two or more disabling relapses within a year and MRI evidence of new areas of MS activity
    • Administration: Oral medication in the form of a pill in two treatment courses, twelve months apart
    • Mavenclad can reduce the number of relapses experienced by about 50% and also reduces number and size of lesions
    • Awaiting decision on reimbursement from the NCPE (Ireland)

Second-line treatment

  1. Gilenya (Novartis)
    • Brand Name: Gilenya
    • Chemical Name: Fingolimod
    • MS type: Adults with relapsing forms of MS; to include the treatment of children and adolescents 10 years of age or older with relapsing MS
    • Administration: Oral medication in capsule form; once a day
    • 54% relapse rate reduction but also benefits on disability, MRI and brain atrophy
    • Click here to read the Gilenya Prescribing Information for healthcare professionals
    • Click here to read the Gilenya Medication Guide for patients
  2. Tysabri (Biogen)
    • Brand Name: Tysabri
    • Chemical Name: Natalizumab
    • MS type: Relapsing forms of MS
    • Administration: Given by infusion; once every four weeks
    • Disabling effects of MS approximately halved and the number of MS attacks decreased by two-thirds in clinical trials
    • Click here to read the Tysabri Prescribing Information for healthcare professionals
    • Click here to read the Tysabri Medication Guide for patients
  3. Ocrevus (Genentech)
    • Brand Name: Ocrevus
    • Chemical Name: Ocrelizumab
    • MS type: Relapsing or primary progressive forms of MS
    • Administration: Taken by intravenous (IV) infusion First full dose as 2 separate infusions, 2 weeks apart. Each infusion will last about 2 hours and 30 minutes Next doses of OCREVUS will be given as one infusion every 6 months. These infusions will last about 3 hours and 30 minutes
    • Reduces number of relapses and number of active lesions in RRMS. Slows or reduces disability progression in PPMS
    • Click to read the Prescribing Information for healthcare professionals
    • Click to read the Medication Guide for patients

Second or third-line treatments

  1. Novantrone
    • Brand Name: Novantrone
    • Chemical NameMitoxantrone
    • MS type 1. Patients with secondary progressive MS 2. Progressive-relapsing MS 3. Worsening relapsing-remitting MS 4. Note:Novantrone has not been approved for the treatment of primary-progressive MS
    • Administration: Taken by intravenous (IV) infusion
    • Click here to read the Novantrone Prescribing Information for healthcare professionals
    • Click here and scroll to page 36 to read the Novantrone Medication Guide for patients
  2. Lemtrada (Genzyme)
    • Brand Name: Lemtrada
    • Chemical Name: Alemtuzumab
    • MS type: Relapsing forms of MS; generally is reserved for people who have had an inadequate response to two or more MS therapies
    • Administration: Taken by intravenous (IV) infusion
    • Reduces the number of MS relapses by about 70% and helps to slow down or reverse some of the signs and symptoms of MS
    • Click here to read the Prescribing Information

Symptomatic treatment

  1. (F)ampyra (Acorda Therapeutics)
    • Brand Name: Fampyra (IRL) / Ampyra (US)
    • Chemical NameDalfampridine
    • SymptomMobility
    • Administration: Oral medication in the form of a pill; twice daily
    • Walking speed improvement
    • Please see the Patient Medication Guide

Note

  • Zinbryta (Biogen)
    • Withdrawn from the worldwide market on March 2, 2018. The European Medicines Agency had raised new safety concerns related to reports of inflammation of the brain or its surrounding tissues (inflammatory encephalitis and meningoencephalitis) among people taking Zinbryta.
    • Brand Name: Zinbryta ® (U.S. and Canada)
    • Chemical Name: daclizumab
    • MS type: Adult patients with relapsing forms of MS. It should be reserved for people who have had an inadequate response to two or more disease-modifying medications.
    • Administration: taken by injection
    • Patient information

Explainer

First-line therapy: Drug therapy that is the first choice for treating a particular condition; other (second-line) drugs are used only if first-line therapy has failed.

Second-line therapy: Treatment that is given when initial treatment (first-line therapy) doesn’t work or stops working.

Source

MS Ireland: Disease Modifying Therapies for Multiple Sclerosis: A Review of the Perspectives of Irish People with MS

National Multiple Sclerosis Society: Medications

MS Trust: How is MS treated?

Disclaimer

The information provided above should not be relied on to suggest a course of treatment for a particular individual, and it should not be used in place of a visit, call, consultation or the advice of a physician or other qualified healthcare provider.

Posted by

Quirky, tenacious and neurologically compromised female expat living in Ireland since 2002 ◾ MyTherapyApp Best MS Blog for Simplicity 2018 ◾ Everyday Health Top 10 MS Blog of 2018 ◾ WEGO Health Patient Leader Award Nominee 2018 ◾ Feedspot Top 50 MS Blog 2017, 2018 ◾ Ireland Blog Award Finalist 2014, 2015, 2017 & Shortlisted 2018 (competition ongoing) ◾ Contributor to the Novartis MS blog Living Like You ◾ Contributor to MS Ireland’s blog MS & Me ◾ Contributor to The Mighty ◾ Guest contributor to MyTherapyApp.com

6 thoughts on “MS Treatments (2018)

  1. Thank you for sharing. It is good to have the education of knowing how the medication make a difference to our inside physical form to our bodies. I’ve been thinking about changing my medication and this helps out.

  2. This was a brilliant post and so informative! It really surprises me how many disease modifying medications there are now because when I was first diagnosed, there were limited options.

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